EXCHANGE
Research units and their teams
Research units
"Mécanismes de la pathogenèse de l'hépatite B et C chronique et nouvelles" Equipe 15
Chronic HBV and HCV infections remain major public health problems worldwide. Major advances in the treatment of chronic hepatitis B and C have been made, but several challenges remain: 1) ...
Biologie à Grande Echelle (BGE) U 1038
In the field of Integrative and Systems Biology, the identity of BGE relies on its activity at the frontiers of innovation in the conception, development and implementation of large-scale approaches, ...
Biology of Cancer and Infection UMR-S 1036; BCI
The main objective of our research laboratory is to increase our understanding of the molecular mechanismms of infection and cancer. and to develop medical applications of diagnostic or therapeutic ...
CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE CIRI Inserm U1111-CNRS UMR5308
The ambition of the CIRI (International Center for Infectiology Research) is to promote an integrated approach on a broad range of host-pathogen interactions and, beyond being recognized as a ...
Cancer Research Center of Lyon UMR INSERM10520-CNRS5286
The Cancer Research Center of Lyon Centre (CRCL) is leaded by A. Puisieux and is dedicated to basic research on oncology.Affiliated to the Inserm, CNRS, UCBL, the CLB and with the Hospices Civils de ...
Center for Molecular and Cellular Genetics and Physiology UMR 5534
CGphiMC teams develop comprehensive approaches to basic cellular processes and aim at deciphering mechanisms by which genetic or epigenetic alterations drive human pathologies. Researches are focused ...
Centre de Recherche sur les Macromolécules Végétales UPR5301
The Cermav is a research laboratory, created in 1966 by the Centre National de la Recherche Scientifique. It works closely with the Université Joseph Fourier and is a part of the Institut de ...
Dysfunction of homeostasis Tissue Engineering and Therapeutics FRE 3310
The fundamental goal of this joint unit between CNRS & University of Lyon1 is to study tissular organization of skin, mucosae and cartilage with regards to its natural integrity and to develop ...
The research program of VirPatH focuses on influenza virus emergence and re-emergence, pathogenesis and host-virus relationships. Our research program analyses: (1) the role of the newly discovered ...
The UMR 5557 is a joint research institute in microbial ecology from CNRS, Université Lyon 1, VetAgro Sup and INRA. It gathers more than 120 research personal focusing on the analysis of ...
Grenoble Institute of Neuroscience GIN U836
Grenoble Institute of Neuroscience federates 13 multidisciplinary research teams devoted to the study of normal and pathological processes in the nervous system. Research topics mainly concern brain ...
INSTITUT DE BIOLOGIE STRUCTURALE UMR 5075
The IBS studies the links between protein structure and function and develops its own research themes while maintaining experimental platforms and undertaking technical innovations. The IBS is close ...
Immunogenomics and inflammation EA4130
Inflammation and cell-cell interactions Autoimmunity with expertise in inflammatory arthritis Cytokines focusing on IL-17 Genomics and biomakers of response to biotherapies
The Albert Bonniot Institute is a founder member of the GIRC: Grenoble Institute of Cancer Research.The Albert Bonniot Institute is a Federative Research Institute (IFR) and it was created in 1999. ...
Institut de Génomique Fonctionnelle de Lyon UMR5242
To understand the function and evolution of genes in animals and their impact on the phenotype, taking into account the action of the environment. IGFL teams aim to identify gene ...
Laboratory Adaptation and Pathogenicity of Microorganisms UMR5163
Understand the fundamental mechanisms of the functioning of different micro-organisms (genetic and epigenetic regulation, physiology, metabolism, evolution ...) and their connection to adaptation and ...
Laboratory of Molecular Biology of the Cell UMR5239
The Laboratory of Molecular Biology of the Cell (LBMC) studies the main questions of modern molecular and cellular biology: genetic and epigenetic regulation of gene expression and genome stability, ...
Microbiologie, Adaptation & Pathogenie UMR5240
The scientific project of UMR 5240 is based on a common interest for the mechanisms of adaptation and pathogenesis of microorganisms. The different teams contribute to this scientific activity by ...
Mucosal Immunity and Pathogen Agent Group (GIMAP) EA 3064
GIMAP (EA 3064) is a multidisciplinary group established in 1991 by immunologists, infectious disease specialists and microbiologists of the University of Saint-Etienne interested by pathophysiology ...
Reroviruses and comparative pathology UMR754
to understand the mechanism of animal retroviruses infection and disease causation
Structural and Molecular Bases of Infectious Systems BMSSI UMR 5086
Research conducted in the unit "Structural and Molecular Basis of Infectious Systems (BMSSI),at IBCP, aim to study the molecular mechanisms of infectious processes causing serious human diseases. The ...
The TIMC-IMAG laboratory gathers scientists and clinicians towards the use of computer science and applied mathematics for understanding and controlling normal and pathological processes in biology ...
Unit of Virus Host Cell Interactions UMI3265
The " Unit of Virus Host Cell Interactions (UVHCI) UMI 3265 UJF-EMBL-CNRS " was created in January 2007 to develop the collaboration between the University Joseph Fourier, the EMBL Grenoble ...
Research teams
13 - RNA INTERFERENCE AND EPIGENETIC
5 - CANCER TARGETS AND EXPERIMENTAL THERAPEUTICS
We analyze the molecular mechanisms that allow tumors to escape conventional treatments in order to develop new targeted therapies and optical-based technologies to treat these cancers. Targeted ...
8 - ANALYTIC IMMUNOLOGY OF CHRONIC PATHOLOGIES
Alternative splicing & tumor progression
Alternative splicing is the main mechanism increasing the proteome diversity coded by a limited number of genes and is therefore likely playing a role in cancer. Using original approaches, we ...
autophagy, infection and immunity
The team is working on the role of autophagy in the contexte of infections. How autophagy is involved in pro- or anti-pathogen biology.
Bacteria and metals: metabolism, homeostasy and resistance
Adaptation and resistance mechanisms of bacteria to trace metals. Biological systems for the detection of polluants (biosensors). Bioremediation.
bacterial infection and inflammasome
We are working on host-pathogens interaction focusing on innate immunity with a particular expertise on the inflammasome pathway. We are studying two bacterial pathogens: -Staphylococcus aureus, a ...
Bacterial Pathogens and Protein Phosphorylation
Our research projects focus on the structural and functional characterization of tyrosine-Kinases (BYK) and eukaryotic-like serine/threonine-Kinases (STPK) found in bacteria. The rationale behind our ...
Bacterial Pathogeny and Cellular Responses
The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Many Gram negative pathogens, some of which provoke serious infections in humans such as diarrhoea, pulmonary ...
Biology of Emerging Viral Infections
UBIVE develops expertise in research, surveillance, diagnosis and prevention of viral zoonoses due to BSL3/4 viruses provoking mostly hemorrhagic fevers. UBIVE hosts a research team mainly focused on ...
Biomolecular NMR spectroscopy group
The Biomolecular NMR spectroscopy group of IBS is developing and using solution and solid state NMR spectroscopy to study structure, dynamics, and interactions of challenging biological systems. The ...
Cell biology and bone physiopathology
We are studying bone physiology through human and murine models using cell biology approach through osteoclasts. Osteoclasts are cells of hematopoietic origin deriving from the monocytic lineage ...
Cell biology of bacterial pathogenicity
Our team is studying the interaction between bacterial pathogens and host cells, with particular interest in identifying bacterial proteins that promote disease. We are actively studying a family of ...
Cell biology of viral infections
Liver fibrosis and hepatitis CLiver fibrosis is associated with the activity of TGF-b. Its evolution term is the liver cirrhosis, first step towards the cellular adenocarcinoma. The HCV-Human ...
We study the molecular mechanisms of the function and the pharmacology of ion channels and other membrane proteins that may associate with them, such as ABC proteins and G-protein coupled receptors. ...
Chemistry and Biotechnology of Oligosaccarides
Synthesis of oligosaccharides and glycoconjugates by chemical, enzymatic and microbial combined approaches. Tools:Engineering of carbohydrate-active enzymes (CAZYmes) and metabolic engineering of ...
Competence development in bacterial pathogens
Bacterial competence for transformation is a genetically programmed physiological state that confers bacteria the ability to naturally acquire and integrate exogenous DNA. Competence is ...
Computational and Mathematical Biology
Research in the team BCM (Computational and Mathematical Biology) is done along three main axes : genomics, systems biology, and mathematical modeling of complex biological systems. Our research ...
Computer-Assisted Medical Interventions
The ultimate objective of the CAMI research group is to assist the physician or surgeon in the successful execution of diagnostic or therapeutic gestures by minimizing invasiveness whilst ...
Understand the functioning of bacterial regulatory networks by a combination of experiments and mathematical modeling.
Dependence receptors, cancer & development
The team works on the dependence receptors, which are able to transduce either a positive (proliferation, survival, guidance) or a negative (apoptosis) signal according to the presence or not of ...
Development, Cancer and Stem Cells
Dynamics and kinetics of molecular processes
Within the group 'Dynamics and Kinetics of Molecular Processes', four independent research teams synergistically develop and apply a broad range of experimental and computational methodologies with ...
Dynamics of Epileptic Synchronous Networks
Our general objective is to better understand the processes through which the neurons that generate epileptic seizures get synchronized just before a seizure and how these processes get into place ...
Endothelial Junctions and Angiogensis
The objectives of the team aum at: - studing the architecture of inter-endothelial junctions by searching the molecular links existing between VE-cadherin and the actin cytoskeleton - measuring the ...
Entry, assembly and egress of enveloped viruses
The main focus of our research centers on the life cycle of HIV-1. We employ structural biology approaches to (i) study the HIV-1 env glycoprotein, a major target for neutralizing antibodies, ...
ENVIRONMENTAL EPIDEMIOLOGY APPLIED TO REPRODUCTION AND RESPIRATORY HEALTH (E2R2H)
The general aim of our research group in environmental epidemiology is to identify preventable risk factors of altered health, focusing on environmental risk factors, and specifically air ...
Epidermis Stress and Differentiation
We are studying the gene networks involved in the cellular response of epidermal cells to genotoxic stresses and their relationships with the cellular differentiation program. We are building the ...
Apicomplexan parasites such as Toxoplasma and Plasmodium take a heavy toll on human health and resources worldwide. Public health programs are deeply concerned about the urgent need for ...
EPIGENETICS AND CELL SIGNALING
The understanding of how genes could be instructed to respond to the driving forces of cell differentiation and development has always been the central focus of our research programs. Our research ...
Epithelium Morphogenesis and Differentiation in Drosophila
My project is to identify the cellular and molecular processes that lead to epithelial cell shape changes during Drosophila follicle development. The ovarian follicular cells modify their adherens ...
Escape from failsafe programs & cellular plasticity
EMT is a latent and reversible embryonic process turning polarized and adjacent epithelila cells into individual motile mesenchymal cells. The hijack of this process is known to facilitate the ...
Essential Kinases in Renal Carcinomas
In 1982, our group provided the first biochemical evidence that Protein kinase CK2 is a tetrameric complex in which the CK2alpha subunits exhibit enzymatic activity whereas the CK2beta subunits ...
Estrogen signalling & breast cancer
Our team is interested in defining the molecular and cellular mechanisms regulating estrogen signaling to assess whether the deregulation of these mechanisms contributes to the ...
Eukaryotic and viral translation
1-Viral translation: IRES, initiation factors 2-HIV-1 and HIV-2 translational control 3-Systemic search for miRNAs in viral genomes (including bioinformatics and functional assays) 4-Design and ...
EVIR - Enveloped viruses, Vectors and Innate Responses
Viruses use, misuse and abuse their hosts to replicate, escape immune responses and invade new cells or organisms. By studying and comparing virus genus and species, we aim to better understand how ...
Evolutionary genomics of fishes
Excitability and Signaling in Normal and Diseased Skeletal Muscle
Our group is interested in skeletal muscle function under control and pathological conditions. We study the mechanisms that control membrane excitability and [Ca2+] in the skeletal muscle cells. ...
Extremophiles and large molecular assemblies
The group works at understanding the mechanisms underpinning basic biological processes by using extremophilic Archaea as model organisms. We specialize on intracellular proteolysis and environmental ...
Functional Genomics of Nuclear Receptors
Functional Genomics of plant pathogenic fungi
In association with the Bayer CropScience phytosanitory company, as part of a joint laboratory, GFCPP team's mission is to contribute to the development of new control strategies against plant ...
Functional NeuroImaging and Brain Perfusion
Our multidiscipinary team works on the development of innovative techniques for acquisition and analysis for Magnetic Resonance Imaging and Spectroscopy (MRI and MRS) and on their preclinical and ...
Genetic Control, Development and Ciliogenesis
Cilia and flagella play key physiological and developmental roles in diverse cell types and organisms. Several human diseases result from defects in cilia. Our work has shown that RFX transcription ...
Genetics and Neurobiology of C. elegans
Our team is using the nematode Caenorhabditis elegans as a genetically tractable model organism to identify new genes and mechanisms involved in the formation and the regulation of synaptic ...
Breast cancer arises following the accumulation of a series of genetic alterations in mammary epithelial cells: most of them are acquired over lifetime (somatic mutations) but some alterations are ...
Genomic and Evolution of Microorganisms (GEM)
We use experimental evolution to investigate the ecological and molecular mechanisms underlying the dynamics of bacterial evolutionary processes and phenotypic traits, including diversification, ...
High-throughput protein technology
Combinatorial methods (e.g. directed evolution, phage display) are used to address problems that are too complex for rational design approaches. Large random libraries of variants are constructed and ...
HIV-genital mucosa interactions and biotherapeutic applications
Main objectives of axis 1: - to better understand the mechanismes of selection of R5 strains during HIV infection by genital route; - to appreciate the respective role of epithelial and immune ...
Host-pathogen interaction during lentiviral infection
Human immunodeficiency viruses (HIVs) are the causal agents of the acquired immunodeficiency syndrome (AIDS), a progressive failure of the immune system that leads to a fatal outcome in the absence ...
Interplay of pathogens with the extracellular matrix to determine the molecular mechanisms underlying tissue tropism (Leishmania), and to identify therapeutic and vaccine targets (Leishmania, ...
Immune Response to pathogens and altered-self (IRPAS group)
The IRPAS group gathers three teams with a common interest for the molecular recognition mechanisms involved in various aspects of the immune response to pathogens and altered self cells, and for the ...
immunity and CD8 cytotoxic cells
Immunity and cytotoxic CD8 T lymphocytes CD8 T cells play a crucial role in adaptive immune responses to pathogens. The generation of memory CD8 T cells is becoming one of the goals of ...
immunity and NK cytotoxic lymphocytes
NK cells are innate lymphocytes that provide an early source of IFNg during infections and kill microbe-infected cells. They are also important in tumor immunosurveillance and in the control of T ...
Immunology of viral infections
Study of innate immune response and pathogenesis of measles virus infection, role of measles virus receptors and Pattern Recognition Receptors RIG-I and MDA-5 and nonstructural C protein in viral ...
Our main objectives are to improve the understanding of how cancer cells take advantage of an inflammatory response by specifically deciphering the contribution of the NLRP3 inflammasome to tumour ...
Inflammation processes in mucosae and epithelia
The 2nd axis of GIMAP is overviewed by Olivier GARRAUD; it is named “Inflammation processes in mucosae and epithelia”; it largely addresses emerging topics that focus on inflammation and ...
Innate immunity signalling & oncogenesis
Three main axes are pursued by the Team: 1- Cell-autonomous role for MyD88 in cancer cells MyD88 is implicated in tumorigenesis through TLR/ IL-1R-mediated pro-inflammatory mechanisms. We have ...
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The group is mainly focused on the molecular investigation of membrane proteins related to pathogen fitness, pathogen-host interactions and immune response. For this, we notably develop new ...
- The homeostasis of metal ions in micro-organisms - Structure-function relationships of metalloenzymes' catalitic sites (X-ray crystallography, QM/MM calculations) - Maturation and assembly of ...
Methods and Electron Microscopy
Structure determination of macromolecular complexes by (cryo-) electron microscopy and electron tomography. The resolution of the 3D reconstruction can be between 30 and 5 A. Main focus on viruses, ...
Molecular Bases of Self-renewal and Alterations
We are working on three projects; - Decipehring the role palyed by ribosomal proteins in v-erbA-indiuced transformation process - Undersatnding the molecualr mechanisms at the origin of ...
The main work objective of our laboratory is to understand how eukaryotic cells adapt to their environment, especially concerning the detection and signaling of glucose. We use the respiratory ...
The team research is focused on the biological activity of complex carbohydrates, either isolated or in interaction with protein receptors such as lectins. Interaction between lectins from human ...
Molecular Mechanisms of Intercellular Communication
Study various aspects of cellular communication at multiple levels, from molecular to multicellular. We are presently focussing on the molecular mechanisms of unconventional secretion of the ...
To ask relevant evolutionary questions and to address these questions through the use of molecular approaches that are available with modern biology. We exclusively study animals and the team name ...
Mucosal immunity, vaccination and biotherapy
The specific goals are oriented towards understanding of the pathophysiological processes involved in induction of immunity versus immune tolerance at mucosal surfaces, with special emphasis on the ...
We study the mechanisms coupling muscle stimulation to muscle contraction, with a focus on calcium release process, both in normal and in pathological muscle (myopathy). The objectives are to ...
Muscle Pathologies in C. elegans
Mechanisms of dystrophin-dependent muscle degeneration in C. elegans Comparative analysis of muscle degeneration in different C. elegans models for muscular dystrophies Mechanims of muscle aging ...
The number, morphology and size of nucleoli are profoundly modified during oncogenesis and constitute one of the most distinctive criteria of cancer cells. These modifications result from sustained ...
Characterization of the endocytic dynamics through 1) the functional dissection of endocytic sorting machineries, in particular the arrestin family of adaptor proteins, and 2) mass spectrometry based ...
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus (over 90% of the human adult population infected). EBV is the causative agent for infectious mononucleosis and is strongly associated with a ...
Paleogenomics and molecular evolution
Pathogenesis of Legionella: from molecular mechanims of virulence to legionellosis
Legionella pneumophila is the main causative agent of the severe pneumonia legionellosis. We are currently investigating molecular basis of L. pneumophila virulence by focusing on the role of ...
Physiological and Pathological Angiogenesis
-Roleof EG-VEGF in physiological (pregnacy) and pathological (pre-eclampsia) placental vascularization and development. -Study of short-lived mRNA stability control by tristetraprolin ...
Physiopathology of orphan nuclear receptors
Our aim is 1- to investigate the effects of ageing and estrogen deficiency (mimicking menopause) on the structure of bone, using in vivo and in vitro models; 2- analyze various parameters of cell ...
Our group is interested in the biology of pneumococcus, an important human pathogen. In particular, we are studying the relationships between the bacterium and its host, the cell wall metabolism and ...
Respiratory physiology has been the original field of scientific activity of PRETA. Our research interests now include the cardio-respiratory interaction in humans, the interactions between cardiac ...
Regulation Networks in Normal and Pathological Myeloid Cells
We aim to understand networks linking extracellular signals, intracellular signalization and transcription factors to the control of normal blood cells production or to the development of ...
Regulatory RNAs and adaptation
Small RNAs (sRNAs) are small size regulators that control various cellular processes. Regulation by sRNAs is advantageous especially when fast responses to external signals are needed. As the ...
Replication of negative strand RNA Virus
The main topic of research focused on the mechanisms of replication of negative strand RNA viruses. The matrix of these viruses for transcription and replication is not an RNA strand bare, but a ...
Our main objectives are to understand the physiopathology of the Human T cell Leukemia Virus Type 1 (HTLV-1) infection and to develop new regimen that could either prevent the occurence of Adult T ...
Retroviruses, evolution and cancer
Retroviruses, Viral Integration and Vaccines
Our team is involved in the study of animal and human retroviruses centred around two axes : (i) fundamental virology, covering the study of the mechanisms of retroviral integration, cellular ...
Cellular senescence is activated by various stresses and results in proliferation arrest. Senescence response has to be bypassed during tumorigenesis process. The aim of the team is to describe ...
Skin allergy, immunity and vaccination
Our research focuses on the mechanisms of skin inflammation leading to immunization or tolerance, using both mouse models and patient's samples, in 2 axes: - Skin inflammatory diseases, particularly ...
SPM (Health, Plasticity, Motricity)
Motor development in healthy and pathological subjects -postural control in children. -cerebral palsy following pre or peri-natal cerebral lesions. Posturo-kinetic ...
Staphylococcal diseases represent a major threat for public health worldwide, accounting for ca. 30% of nosocomial and community-acquired infections. Staphylococcal pathogenesis depends on the ...
Stress and Neuro-digestive Interactions (SIND)
Brain-gut interactions with a special interest in the effect of stress on inflammatory bowel disease (IBD) and functional diegstive disorders as represented by irritable bowel syndrome (IBS) as well ...
Structural biology of bacterial macromolecular complexes
Bacterial infection relies on the micro-organism’s ability to adapt to its environment, subvert the immune system and multiply into its host. Our laboratory uses Biochemistry, X-ray ...
Structural Biology of signal transduction and epigenetic gene regulation
Previous and current research Cellular control logic is ultimately embedded in the molecular architecture of the molecular machines that make up the living cell. Many molecular machines, especially ...
Structure and Activity of Glycosaminoglycans (SAGAG)
Our researches focus on a group of polysaccharides collectively known as glycosaminoglycans (GAGs) which comprise heparin, heparan sulphate, chondroitin and dermatan sulphate, keratan sulphate and ...
The Synchrotron Crystallography team at the EMBL-Grenoble works on the design, construction and operation of macromolecular and biological Small angle X-ray scattering beamlines at the ESRF. We also ...
Transforming growth factor beta (TGF-b) is a master regulatory cytokine of the immune system. Its absence leads to massive autoimmunity touching all the organs. Interestingly this ...
TGFß Family in Angiogenesis and Lymphangiogenesis
The objectives of the team are to further characterize the role of BMP9 in angiogenesis, and its structure with ALK1 in order to investigate BMP9/ALK1 as a new therapeutic target in vascular diseases ...
The high-throughput crystallisation laboratory
The HTX lab is one of the major facilities for high-throughput nanovolume crystallization screening in Europe and one of the main resources of the Partnership for Structural Biology in ...
Therapeutic targeting of the tumor & of its immune environment
The immune system is one of the main barriers protecting the organism from tumor development. Nevertheless, the immune system may facilitate tumor progression through multiple yet poorly known ...
Our research is organized along three main complemental lines, clinical proteomic, rational design of therapeutic proteins and vectors, and host – pathogen interaction, together with two ...
Viral Infection and Cancer (VIC)
Our group is interested in how key intracellular processes are subverted during viral infection and cancer, and in using this knowledge to develop new strategies for fighting disease.The group is ...
Viral molecular factors and functional host cell interactions
The aim of our research programs is to generate additional knowledges about fundamental biology of influenza viruses and their host functional relationships. (i) We are studying molecular and ...
Virulence factors of phytopathogenic bacteria
Axe 1. Metabolism and metabolites involved in the virulence of Dickeya dadantii: metabolic pathways induced during plant infection, main metabolites and their roles in signalisation. Axe 2. ...
The team has two main interests: (i) first, the in vivo study, in mouse model, of the role of the nuclear organization and nuclear domains such as PML nuclear bodies (or ND10) and centromeres in the ...
Towards a better knowledge of RNP biology and assembly Influenza A virus consists of 8 negative single stranded RNA segments organized as viral ribo-nucleoprotein complexes (vRNPs). During budding, ...
Virus structure and electron microscopy development
Structure determination of macromolecular complexes by (cryo-) electron microscopy and electron tomography. The resolution of the 3D reconstruction can be between 30 and5 A. Main focus on viruses, ...
Viruses, vectors and the Nucleus
The research projects developed by this team concern:(i) the analysis of function-dependent interactions between nuclear replicating viruses and nuclear environment, and (ii) the development of ...
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