EXCHANGE
Research unit
Laboratory Adaptation and Pathogenicity of Microorganisms
General information on reserch unit
Unit code : UMR5163
Organizations attachment : CNRS
Address : Université Joseph Fourier, Domaine de la Merci Institut Jean Roget
City : La Tronche
Zip code : 38700
Attached organisms : CNRS
Objectives of the unit : Understand the fundamental mechanisms of the functioning of different micro-organisms (genetic and epigenetic regulation, physiology, metabolism, evolution ...) and their connection to adaptation and pathogenicity. The major organisms studied are bacteria and parasites. We carry out fundamental research in microbiology, evolutionary biology, systems biology, parasitology, cell biology, biochemistry and immunology. Results from fundamental research are compared and applied to organisms and questions of medical and biotechnological interest.
Contact
First name : Dominique
Last name : Schneider
Position : unit director
Email : dominique.schneider@ujf-grenoble.fr
Phone : +33(0)4 76 63 74 90
Research teams
Unit information
| Number of employees | 33 | |
| Number of lecturers-researchers | 11 | |
| Number of researchers | 10 | |
| Number of post-doctoral associate | 6 | |
| Number of PhD student | 7 | |
| Number of administrative and non-researcher staff | 12 |
Research unit Segmentation
Bacteriology, Biochemistry , Biostatistics - Bioinformatics, Diagnosis, Genetic/genomic, Host-pathogens relationships, Immunology, Inflammatory process, Multi-drug resistance, Mycology-Parasitology
Main results and highlights
Experimental evolution allows a dynamic understanding of the forces and mechanisms that shape bacterial phenotypic and genomic traits.
The combination of experimental data of the dynamics of gene expression with mathematical models allows us to understand the functioning of large bacterial genetic and metabolic networks.
Drug inhibition of a histone deacetylase allows to control the epigenetic differentiation of Toxoplama gondii.
Identification of a genetic locus that renders rats resistant against an infection by Toxoplasma gondii.
